Opportunities / HEALTH AND HUMAN SERVICES, DEPARTMENT OF

Health Science Futures (HSF) Mission Office Innovative Solutions Opening (ISO)

Notice typeSolicitation
Solicitation #ARPA-H-SOL-24-104
DepartmentHEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier / officeNATIONAL INSTITUTES OF HEALTH / ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH (ARPA-H)
NAICS541715 — Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
PSCAN13
Set-asideNone
PostedNov 13, 2025
Response deadlineMar 6, 2029 (2029-03-05T23:59:00-05:00)
Place of performance—
Primary contactSEE DESCRIPTION SECTION · do_NOT_use_THIS_email_ADDRESS@arpa-h.gov

Description (excerpt)

This ISO seeks solution summaries and proposal submissions for projects that fall within the general scope of the ARPA-H Health Science Futures (HSF) mission office. HSF expands what is technically possible by developing approaches that will remove the scientific and technological limitations that stymie progress towards the healthcare of the future. HSF supports cutting-edge, often disease-agnostic research programs that have the potential for translational real-world change. Solution summary submissions must be submitted to: https://solutions.arpa-h.gov Questions must be submitted to: https://solutions.arpa-h.gov/Ask-A-Question/ Proposal submission should be submitted to: https://solutions.arpa-h.gov/Submit-Proposal/ Amendment 3 is effective immediately; however, if an entity has previously submitted a solution summary and/or a proposal, the prior solicitation(s) will be followed for those submissions. If a solution summary is submitted; however, a proposal has not been submitted yet, the proposal will be evaluated in accordance with this amendment. The following updates were made to the proposal documents: 1) Administrative & National Policy Requirements Document Updated the instructions and references within the “Organizational Conflicts of Interest (OCI) Affirmations and Disclosure” section. Updated questions, instructions, and content within the “Research Security Disclosure” section. Updated the instructions and intellectual property data assertions charts within the “IP” section. This included providing definitions of rights categories (unlimited, government purpose, limited, and specially negotiated/other) and consolidating two data assertions charts into one to assist proposers more efficiently complete the document. Specifically, the “Non-Commercial” and “Commercial” tables were removed and replaced with the “Background IP and Data Assertions” table. Eliminated the “Software Component Standards” section. Updated the Human Subjects Research (HSR) table within the “HSR” section. Updated the Animal Subjects Research (ASR) table within the “ASR” section. Updated the questions and instructions within the “Biosecurity” section. 2) Cost Proposal Document (Word document) Updated the instructions within the “Level of Effort and Labor Costs” section. Added definitions for “burdened labor rate” and “fully burdened labor rate” to provide clarity for proposers when completing the document. Also added a statement to clarify that fully burdened labor rates are …

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